Alinidine
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| Clinical data | |
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| ATC code | none |
| Legal status | |
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| Identifiers | |
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| CAS Number |
33178-86-8  N |
| PubChem (CID) | 36354 |
| ChemSpider |
33429  Y |
| UNII |
E7IDJ8DS1D Y |
| ChEMBL |
CHEMBL278581 Y |
| Chemical and physical data | |
| Formula | C12H13Cl2N3 |
| Molar mass | 270.16 g/mol |
| 3D model (Jmol) | Interactive image |
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| NY (what is this?) (verify) | |
Alinidine (ST567) is a negative chronotrope that was developed in the 1970s and 1980s. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold.[1] The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.[2]
Alinidine did not improve outcomes among patients with acute myocardial infarction in a randomized controlled trial.[3]
References
- ↑ Snyders DJ, Van Bogaert P-P: Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflugers Arch 1987, 410:83-91
- ↑ Current Opinion in Pharmacology 2007, 7:208–213
- ↑ Van de Werf F, Janssens L, Brzostek T, Mortelmans L, Wackers FJ, Willems GM, et al. (1993). "Short-term effects of early intravenous treatment with a beta-adrenergic blocking agent or a specific bradycardiac agent in patients with acute myocardial infarction receiving thrombolytic therapy.". J Am Coll Cardiol. 22 (2): 407–16. doi:10.1016/0735-1097(93)90044-2. PMID 8335810.
| Sympatholytics (antagonize α-adrenergic vasoconstriction) |
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| Calcium (Ca2+) |
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| Potassium (K+) |
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| Chloride (Cl−) |
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